منابع مشابه
Effects of uricosuric drugs and diuretics on uric acid excretion in oxonate-treated rats.
A practical procedure for evaluating uricosuric agents was demonstrated using clearance experiments with potassium oxonate-treated rats. The fractional excretion value of uric acid showed a reabsorptive net flux of uric acid in the renal tubules of the animal, though the value was obviously higher than those of primates such as men, chimpanzees and cebus monkeys. However, the rats responded wel...
متن کاملPharmacology of uricosuric drugs.
When the level of uric acid, primarily in the form of monosodium urate (Wilcox, Khalaf, Weinberger, Kippen, and Klinenberg, 1972), exceeds the point of maximum solubility, crystals of monosodium urate may then form, particularly in the joints and connective tissues. These crystals initiate attacks of acute gout (Buchanan, Klinenberg, and Seegmiller, 1965; Seegmiller, 1965; Weissmann, 1971), and...
متن کاملUricosuric targets of tranilast
Uric acid, generated from the metabolism of purines, has both proven and emerging roles in human disease. Serum uric acid in humans is determined by production and by the net balance of reabsorption and secretion in kidney and intestine. In the human kidney, epithelial reabsorption dominates over secretion, such that in normal subjects there is at least 90% net reabsorption of filtered urate re...
متن کاملEvaluation of uricosuric agents in chronic gout.
Experience gained during the past 7 years with the prolonged administration of probenecid (Pascale, Dubin, and Hoffman, 1952; Talbott, 1953; Gutman and Yu, 1955; Bartels, 1955; Bauer and Singh, 1957) or of salicylates (Marson, 1953, 1954, 1955) has shown that continuous therapy with a uricosuric agent in effective doses, is the only practical method at present available for preventing the compl...
متن کاملOrigins of the uricosuric response.
The acute effects of intravenous (i.v.) probenecid and chlorothiazide on renal urate handling were investigated in paired studies in normal men. Uricosuric responses to these agents were compared in the same subjects, both without and with pyrazinamide (PZA) pretreatment. Assuming that PZA selectively inhibits the tubular secretion of urate and that uricosuric agents act by increasing the excre...
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ژورنال
عنوان ژورنال: Kidney International
سال: 1980
ISSN: 0085-2538
DOI: 10.1038/ki.1980.185